姓 名:阿布拉江·克依木
职称/职务:教授 、博士、博/硕士生导师
专 业:有机化学
研究方向:有机合成、绿色合成、天然药物等
出生年月:1976.12
联系方式:13999135640
邮 箱:ablajan209@hotmail.com, ablajan209@xju.edu.cn
办公室:皇冠-315 实验室:312、314 室
个人经历
2016/04–2017/05, 美国宾夕法尼亚大学,访问学者
2015/09–2016/01, 西安外国语大学,英语培训
2008/09–2010/10, 新疆医科大学 药学院博士后流动站,博士后
2009/09–2010/07, 中国医学科学院, 药物研究所, “西部之光”访问学者
2003/08–2006/07, 中国医学科学院 药物研究所, 理学博士
2000/09–2003/07, 新疆大学,有机化学,硕士
2014/11-至今,皇冠hg8868老版本,化学化工学院,教授
2006/07-2014/10,皇冠hg8868老版本,化学化工学院,副教授
1999/08–2000/09, 新疆维吾尔自治区卫生厅,科研员
主讲课程
本科生:《有机化学》、《有机化学实验》、《天然药物化学》
研究生:《天然药物化学》
研究内容
1. 有机合成及其方法学、绿色合成
2. 药物合成、关键中间体及功能有机分子的设计与合成
3. 中药材有效成分的分离与分析
主持科研项目
1. 上合组织国际合作项目,基于光催化和金属协同催化的二氧化碳的转化利用以及 C-H 键官能化和羧基化研究,2022.10-2025.10,主持
2. 自治区自然科学基金(面上),光催化的惰性 C-H 键官能化研究,2022.12–2025.12,主持
3. 国家自然科学基金项目, 基于多组分一锅反应的药物关键中间体的合成方法研究,2020.1–2023.12,主持
4. 武汉光电国家研究中心(华中科技大学)开放基金,基于阿尔兹海默症小胶质细胞靶向标记荧光探针的开发及其对疾病进展诊断检测,2021.1–2023.12,主持
5. 国家自然科学基金项目, 多取代嘧啶、哒嗪并咪唑及吲哚螺吡喃等功能杂环类化合物的多组分一锅法合成研究,2015.1–2018.12,主持
6. 国家自然科学基金项目, 维药复方复杂体系中有效成分的分离与分析方法研究,2012.1–2013.12,主持
7. 自治区“杰出青年”科技人才培养项目,2016.1–2018.12,主持
8. 自治区天山英才工程第二层次培养计划,新疆维吾尔自治区人力资源和社会保障厅,主持
9. 中国科学院“西部之光”人才培养计划,维药材“对叶大戟”活性物质、有效部位及其质量标准研究, 2012.1-2015.12,主持
10. 新疆科技厅自然科学基金项目,维药复方苏孜阿甫有效成分的分离与分析研究,2012.1-2015.12,主持
11. 中国博士后科学基金,主持
11. 自治区高校科研计划项目, 维药野苜蓿中异黄酮类成分的分离与分析研究,2010.1-2011.12主持
奖励情况:
1. 皇冠hg8868老版本优秀论文奖,2016年,排名第二,通讯作者;
2. 中华科学技术奖三等奖,药物复杂体系多组分及功能分子结构表征的质谱分析新方法,2011年,排名第六;
3.获得北京市科学技术奖二等奖, 功能分子结构及药物复杂体系多组分的质谱分析新方法,2010年,排名第六;
个人荣誉
2012年获第二届皇冠hg8868老版本青年科技奖;
2009年被选为自治区优秀博士后资助人员;
2009年中药创新论坛优秀论文奖;
2006年西部地区支援奖,北京市教育局;
社会工作
《合成化学》 编委 (2019-)
代表性研究成果
1. Yunfei Jia, Ping Jiang, Xinqian Wang, Keyume Ablajan*, One-Pot, Metal-Free Synthesis of Allyl Sulfones in Water, J. Org. Chem. 2024, 89, 2, 835–843
2. Fang Liu, Akbar Sohail, Keyume Ablajan*, Metal-F ree Oxidative Formation of Aryl Esters by Catalytic Coupling of Acyl and Sulfonyl Chlorides with Arylboronic, J. Org. Chem. 2024, 89, 1, 27–33
3. Long Ji, Keyume Ablajan*, Metal-Free K2S2O8-Mediated Direct Hydrazonation of Methylene in Pyrazoline-5-ones, Asian J. Org. Chem., 2024, e202300577.
4. Xin Ge, Ping Lei, Qin Su, Ying-Ming Pan, Keyume Ablajan*, I2-Catalyzed Oxidative Acylation of Tertiary Amines via C–N Bond Cleavage, Synthesis, 2024, 10.1055/a-2256-983.
5. Y. Jia, K. Ablajan.* N‐Chlorosuccinimide‐Promoted One‐Pot Synthesis of Substituted 4,5‐Dihydroisoxazole‐5‐ methanols in Aqueous Medium, Adv. Synth. & Catal., 2023, 365,244–251.
6. Long Ji, Keyume Ablajan*, Synthesis of N-Phenylcarbamate by C–N Coupling Reaction without Metal Participation, Synthesis, 2023, 55(19): 3113–3120.
7. 8.景智霞, 杜建喜, 蒋平, 阿布拉江•克依木*,四丁基碘化胺介导烷基酰胺与酰肼一锅法构建1,3,4-噁二唑衍生物,有机化学,2023, 43 (11): 3930–3938.
8. L. Tian, Q. Zhang, K. Ablajan.* Iodine-Promoted N-Acylation of Amines with Hydrazide: An Efficient Metal-Free Amidation, Synthesis, 2022, 54, 54(19): 4353–4360.
9. H. Ma, J. Liang, K. Ablajan.* One-pot synthesis of multisubstituted spirocyclopropanes mediated by α-picoline, New J. Chem., 2022, 46, 19857–19862
10. B. Wang, Q. Zhang, Z. Guo, K. Ablajan*. Iodine- and TBHP-Promoted Acylation of Benzothiazoles under Metal-Free Conditions, Synthesis, 2020, 52, 3058–3064.
11. Q. Zhang, K. Ablajan*, B. Wang, H. Ma, Z. Guo. One-pot synthesis of indolizinesusing TBHP as the methylene source under metal-free condition. European Journal of Organic Chemistry, 2020, 16, 262-266.
12. Q. Zhang, B. Wang, H. Ma, K. Ablajan*. Transition-metal-free catalyzed [3+2] cycloadditions/ oxidative aromatization reactions for the synthesis of annulated indolizines. New Journal of Chemistry, 2019, 43, 1700-1703.
13. R. Ruzi, M. Zhang, K. Ablajan*, C. Zhu*. Photoredox-Catalyzed Deoxygenative Intramolecular Acylation of Biarylcarboxylic Acids: A Facile Access to Fluorenones. Journal of Organic Chemistry, 2017, 82, 12834−12839.
14. K. Ablajan, G. B. Panetti, X. Yang, B. Kim, P. J. Walsh. Synthesis of diarylated 4-pyridylmethyl ethers via palladium-catalyzed cross- coupling reactions. Advanced Synthesis & Catalysis, 2017, 359, 1927-1932.
15. A. Omar, K. Ablajan*, M. Hamdulla. Cetyltrimethylammonium chloride (CTAC) catalyzed one-pot synthesis of novel coumarin-4H-pyran conjugates in aqueous media. Chinese Chemical Letters, 2017, 28, 976–980.
16. W. Li, R. Ruzi, K. Ablajan*, Z. Ghalipt. One-pot synthesis of highly functionalized pyrano[2,3-c]pyrazole-4,4′-diacetate and 6-oxo-pyrano[2,3-c]pyrazole derivatives catalyzed by urea. Tetrahedron, 2017, 73, 164–171.
17. M. Seydimemet, K. Ablajan*, M. Hamdulla, W. Li, L-Proline catalyzed four-component one-pot synthesis of coumarin-containing dihydropyrano[2,3-c]pyrazoles under ultrasonic irradiation. Tetrahedron, 2016, 72, 7599-7605.
18. L. Wang, K. Ablajan*, J. Feng. Rapid and efficient one-pot synthesis of spiro[indoline-3,4′-pyrano[2,3-c]pyrazole] derivatives catalyzed by L-proline under ultrasound irradiation, Ultrasonics Sonochemistry, 2015, 22, 113–118.
19. J. Feng, K. Ablajan*. A. Sali. 4-Dimethylaminopyridine-catalyzed multi-component one-pot reactions for the synthesis of [indoline-3,4′- pyrano[2,3-c]pyrazole] derivatives, Tetrahedron, 2014, 70, 484–489.
20. L. Wang, K. Ablajan*. Pyrrolidine-catalyzed four-component one-pot synthesis of dihydropyrano[2,3-c]pyrazole derivatives, Current-Organic Synthesis, 2014, 70, 309–316.
21. K. Ablajan*, L. Wang, Y. Kelimu, F. Jun. Cerium ammonium nitrate (CAN)-catalyzed four-component one-pot synthesis of multi-substituted pyrano[2,3-c] pyrazoles under ultrasound irradiation, Molecular -Diversity, 2013, 17, 693–700.
22. 冯俊, 阿布拉江·克依木*, 马夏冰, 李文博, 麦麦提艾力·奥布力. 多组分反应合成螺吲哚-吡喃并[2,3-c]吡唑类化合物的研究. 有机化学, 2016, 36(1), 222–228.
23. Fulian Zhan, Yongting Lu, Wetengul Kamil,K. Ablajan*. Chemical Constituents of Euphorbia sororia from Xinjiang, Chemistry of Natural Compounds, 2015, 51(3), 561–562.
24. K. Ablajan*, Zeynepgul Esmayil, Liju Wang, Feng Jun. DABCO catalyzed efficient synthesis of multi-substitutedpyrano[2,3-c]pyrazole-4-carboxylate via a one-pot reaction, Tetrahedron, 2014, 70, 3976–3980.
25. Jun Feng, K. Ablajan*. Ahat Sali. 4-Dimethylaminopyridine-catalyzed multi-component one-pot reactions for the synthesis of [indoline-3,4′- pyrano[2,3-c]pyrazole] derivatives, Tetrahedron, 2014, 70, 484–489.
26. K. Ablajan*, Li-Ju Wang, Zulipiya Maimaiti, Yong-Ting Lu. CeCl3-promoted one-pot synthesis of multisubstitutedbispyrano[2,3-c]pyrazole derivatives. Monatsh. Chem., 2014, 145, 491–496.
27. K. Ablajan*, AnaguTuoheti. Fragmentation characteristics and isomeric differentiation of flavonol O-rhamnosides using negative ion ESI–MS. Rapid Commun Mass Spectrom., 2013, 27, 451–460.
28. N. Guo, K. Ablajan, Fan B, Yan H, Yu Y. Simultaneous determination of seven ginsenosides in Du Shen Tang decoction by rapid resolution liquid chromatography (RRLC). Food Chemistry, 2013, 141, 4046–4050.
29. 王立举,阿布拉江·克依木*. Cs2CO3催化三组分“一锅法”合成5-氨基-7-芳基-7,8-二氢-[1,2,4]三唑并[4,3-a]嘧啶-6-腈衍生物[J].有机化学, 2013, 33(10), 2205–2209.
30. K. Ablajan*, Wetengul Kamil, Anagu Tuoheti, Sun Wanfu,An efficient three component one-pot synthesis of 5-amino-7-aryl-dihydro-triazolo[4,3-a]pyrimidine-6-carbonitriles. Molecules, 2012, 17(2), 1860–1869.
31. Zulipiya Maimaiti, K. Ablajan. An efficient four-component synthesis of multisubstituted pyrano[2,3-c]pyrazole. Synthetic Communication, 2012, 42(13), 1959–1966.
32. K. Ablajan*, Hainimu Xiamuxi. An efficient one-pot synthesis of β-unsaturated isoxazol-5-ones and pyrazol-5-ones under ultrasonic irradiation. Synthetic Communication, 2012, 42(8), 1128–1136.
33. 阿布拉江·克依木*, 王立举. 3-(2-萘基)-1-苯基-吡唑-4-甲醛腙衍生物的简便合成与表征. 有机化学, 2012, 32(12), 2358–2362.
34. K. Ablajan. A study of characteristic fragmentation of isoflavonoids by using negative ion ESI-MS. Journal of Mass Spectrometry, 2011, 46, 77–84.
35. KeyumeAblajan*, Hainimu Xiamuxi. The convenient synthesis of 4-arylmethylidene-4,5- dihydro-3-phenylisoxazol-5-ones. Chinese Chemical Letters, 2011, 22(2), 151–154.